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CAS Dalian Institute of Chemical Physics: .alpha.-alkenes from engineered yeast

The group of Yongjin ZHOU at CAS DICP, in collaboration with Jens NIELSEN at Chalmers University of Technology, has engineered S cerevisiae to produce long-chain .alpha.-alkenes from fatty acids and secrete them into the medium. Key enzymes engineered into the strain were UndB, a membrane-bound decarboxylase from P. fluorescens not dependent on hydrogen peroxide, and a long-chain fatty acid transporter FATP1. Metabolic dynamic regulation was used to balance cell growth and product synthesis, and led to α- alkene production of 35.3 mg/L, of which >80% was secreted.

Source: CAS news release, March 8, 2018

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